Light-to-Heat Photothermal Dynamic Properties of Polypyrrole-Based Coating for Regenerative Therapy and Lab-on-a-Chip Applications

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Ulasevich S., Ryzhkov N. V., Andreeva D. V., Ozden D. S., Piskin E., Skorb E. V.

ADVANCED MATERIALS INTERFACES, cilt.7, sa.21, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 21
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1002/admi.202000980
  • Dergi Adı: ADVANCED MATERIALS INTERFACES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Applied Science & Technology Source, Compendex, INSPEC
  • Anahtar Kelimeler: mesoporous titania, polyelectrolytes, polymer coating, polypyrrole, ultrasonic treatment, CONTROLLED-RELEASE, ULTRASONIC CAVITATION, COMPOSITE SCAFFOLD, TITANIUM SURFACES, DRUG-DELIVERY, GROWTH-FACTOR, IN-VITRO, NANOPARTICLES, MICROCAPSULES, FABRICATION
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Targeted delivery and release of biomolecules, e.g., bone morphogenetic protein (BMP-2), are gaining high interest due to the application for tissue engineering, diagnostics, surface-enhanced therapy and lab-on-a-chip. Here, a new hybrid temperature-responsive system consisting of polypyrrole (PPy) layer, mesoporous titania surface (TMS), and BMP-2 is proposed. The PPy layer has the light-to-heat photothermal property. Dynamic behavior of the PPy layer in response to light can regulate release of BMP-2. The PPy-based coatings on TMS have shown to be efficient for storage of BMP-2 and can be tuned to release BMP-2 under irradiation. Moreover, the possibility of local delivery and generation of a gradual release of BMP-2 for regulated cell growth is shown. Furthermore, the fabricated surfaces possess excellent biocompatibility and low cytotoxicity for MC3T3-E1 cells. It is shown that the released BMP-2 can effectively promote osteogenic differentiation of MC3T3-E1 cells. Thus, the TMS/PPy-BMP-2 is suggested to prolong targeted release of the BMP-2 for more than 25 days which stimulates osteoblasts' proliferation. The new stimuli-responsive hybrid system is promising for targeted, localized, sustained drug release and application in bone tissue engineering.