Effects of Rumex patientia root extract on indomethacine and ethanol induced gastric damage in rats

SULEYMAN H., Demirezer L. Ö., KURUUZUM-UZ A.

PHARMAZIE, vol.59, no.2, pp.147-149, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 2
  • Publication Date: 2004
  • Journal Name: PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.147-149
  • Hacettepe University Affiliated: Yes

Abstract

The effects of an aqueous root extract from Rumex patientia (D-1) compared to COX-2 selective inhibitors on indomethacine and ethanol induced stomach ulcers were investigated. Adult male Wistar albino rats, weighing between 185-200 g were used. It was determined that D-1 does not show its gastroprotective activity via a COX enzyme in indomethacine induced ulcers. Antioxidant effects protect the gastrointestinal system. The effect of D-1 in ethanol induced ulcers may also be due to its antioxidant effect.