Decreased vitamin D levels in children and adolescents with Celiac disease: A nationwide cross-sectional study


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AKELMA A. Z., Keskin M., Erdeve Ş. S., BURSA N., Çelik O., İmrat E., ...More

Gulhane Medical Journal, vol.64, no.3, pp.268-273, 2022 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.4274/gulhane.galenos.2022.38039
  • Journal Name: Gulhane Medical Journal
  • Journal Indexes: Scopus, Academic Search Premier, CAB Abstracts, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.268-273
  • Keywords: 25-hydroxyvitamin d, Gluten-free diet, Transglutaminase antibody, Vitamin d deficiency
  • Hacettepe University Affiliated: Yes

Abstract

© Copyright 2022 by the University of Health Sciences Türkiye, Gülhane Faculty of Medicine / Gülhane Medical Journal published by Galenos Publishing HouseAims: Vitamin D deficiency results from malabsorption in Celiac disease (CD), and it may also be involved in the pathogenesis of CD. There is no clarity regarding vitamin D deficiency in CD. We investigated the frequency of vitamin D deficiency in children with CD compared with controls. Methods: The database of the Turkish Ministry of Health was used for the cross-sectional descriptive study. Children with CD whose serum tissue transglutaminase (tTG) and serum 25-hydroxyvitamin D [25(OH)D] levels were available in the registry were included. The CD group was further subdivided into tTG (IgG and/or IgA) antibody-negative and positive subgroups. Individuals with CD were classified as compatible and non-compatible with a gluten-free diet (GFD) (GFD-compatible and GFD-non-compatible groups), respectively. Children who had no known malabsorption syndrome formed the control group. Results: The median serum 25(OH)D level was 18.5 ng/mL in children with CD (n=6717) and 30.7 ng/mL in the control group (n=6717) (p<0.001). The vitamin D levels of the GFDcompatible (n=1102) and GFD-non-compatible groups (n=5615) were 19.36 ng/mL and 18.30 ng/mL, respectively (p<0.001). The rate of vitamin D deficiency was 56% in the CD group and 12% in the control group (p<0.001). Conclusions: This study found significantly lower serum vitamin D levels in children and adolescents with CD. The results suggest children with CD should be evaluated for vitamin D levels and followed periodically