This study was carried out on 34 lower limb amputees in order to investigate the effect of three different physiotherapy approaches on pain patterns of amputees for Buerger's disease. Amputees were divided into three groups. Connective tissue manipulation (CTM) and interferential therapy (IT) were applied to the first and second groups combined with an exercise programme and prosthetic training. The third group followed only the exercise programme and prosthetic training. Amputees underwent pain assessments before and after the treatment including intensity, quality and localisation of pain. Significant differences were found between pre- and post-treatment pain values of all groups (p < 0.05) but especially in the groups treated by CTM and IT.