Monoamine oxidase inhibitory activity of 2-aryl-4H-chromen-4-ones


Nayak B. V. , Ciftci-Yabanoglu S., Bhakat S., Timiri A. K. , Sinha B. N. , UÇAR G. , ...More

BIOORGANIC CHEMISTRY, vol.58, pp.72-80, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 58
  • Publication Date: 2015
  • Doi Number: 10.1016/j.bioorg.2014.11.008
  • Title of Journal : BIOORGANIC CHEMISTRY
  • Page Numbers: pp.72-80

Abstract

A series of twenty 2-aryl-4H-chromen-4-one (flavones) derivatives (3a-3s) were synthesized and tested for hMAO inhibitory activity. Fifteen compounds (3a, 3c, 3e-3h, 3j-3p, 3r, 3s) were found to be selective towards MAO-B, while 3d was selective towards MAO-A, and 3b, 3i and 3q were non-selective. Experimental Selectivity Index for MAO-B ranges from 2.0 (3g, 3p) to 30.0 (3j). Compound 3j, which is carrying 3,4-di-OMeC6H3 groups at R position on the molecule, was found to be potent MAO-B inhibitor amongst the fifteen with K-i value for MAO-B of 0.16 +/- 0.01 mu M comparable to that of standard drug, Selegiline (Ki for MAO-B is 0.16 +/- 0.01 mu M). Compound 3j also appeared as the most selective MAO-B inhibitor according to its best selectivity index (30.0), which is comparable to that of Selegiline (SIMAO-B = 35.0). Molecular docking and molecular dynamics simulation studies were carried out using Autodock-4.0 and Amber12 to understand the molecular level interaction and energy relation of MAO isoforms with selective inhibitors (3d and 3j). Simulation results are in good agreement with the experimental results. Leads identified may further be explored to develop potent isoform specific inhibitors of MAO. (C) 2014 Elsevier Inc. All rights reserved.