Chanarin-Dorfman Syndrome with Multi-System Involvement in Two Siblings

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Camlar S. A., Gencpinar P., MAKAY B., YÜZBAŞIOĞLU A., ARSLAN N., DÖKMECİ S., ...Daha Fazla

TURKISH JOURNAL OF HEMATOLOGY, cilt.30, sa.1, ss.72-75, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.4274/tjh.93798
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.72-75
  • Anahtar Kelimeler: Ichthyosis, Child, Chanarin-Dorfman syndrome, LIPID STORAGE DISEASE, CLINICAL-FEATURES, ICHTHYOSIS, CGI-58
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Chanarin-Dorfman syndrome (CDS) is a very rare autosomal recessive inherited neutral lipid metabolism disorder associated with congenital ichthyosis and multi-system involvement. Observation of lipid vacuoles in neutrophils (Jordan's anomaly) in peripheral blood smears in patients with ichthyosiform erythroderma is diagnostic. Herein we present 2 siblings with CDS that were referred to Dokuz Eylul University School of Medicine Department of Pediatrics due to ichthyosis. They had hepatomegaly, cataract, growth retardation, and sensorineural hearing loss. Some lipid vacuoles in neutrophils were noted in peripheral blood smear evaluation. Genetic analysis showed homozygous N209X mutation in both patients. They were put on a low-fat high-carbohydrate diet supplemented with medium-chain fatty acids. During 6 months of follow-up, no improvement was observed in both patients. In conclusion, although CDS is a rare lipid storage disease, it should always be a consideration in patients with congenital ichthyosis, especially those with extracutaneous symptoms or signs. The diagnosis of CDS is made based on a very simple test-peripheral blood smear.