Colchicine and Leukopenia: Clinical Implications

Sag, ERDAL; Bayindir, Yagmur; Adiguzel, Aydin; Demir, Selcan; Bilginer, Yelda; Aytac, ŞEVKİYE; Ozen, Seza

doi:10.1016/j.jpeds.2020.03.065

Colchicine and Leukopenia: Clinical Implications

Sag E. , Bayindir Y., Adiguzel A., Demir S., Bilginer Y., Aytac Ş. S. , ...More

JOURNAL OF PEDIATRICS, vol.224, pp.166-171, 2020 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 224
Publication Date: 2020
Doi Number: 10.1016/j.jpeds.2020.03.065
Title of Journal : JOURNAL OF PEDIATRICS
Page Numbers: pp.166-171

Abstract

Colchicine is the mainstay of treatment for familial Mediterranean fever. We investigated the frequency of leukopenia in 213 patients with familial Mediterranean fever treated with standard doses of colchicine (0.5-2.0 mg/day). We found that 23 patients (10.8%) had reversible leukopenia, 3 moderate, and none severe and that their rate of infections was not increased.