Colchicine and Leukopenia: Clinical Implications

Sag E., Bayindir Y., Adiguzel A., Demir S., Bilginer Y., Aytac Ş. S., ...More

JOURNAL OF PEDIATRICS, vol.224, pp.166-171, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 224
  • Publication Date: 2020
  • Doi Number: 10.1016/j.jpeds.2020.03.065
  • Journal Name: JOURNAL OF PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Sociological abstracts, Veterinary Science Database
  • Page Numbers: pp.166-171
  • Hacettepe University Affiliated: Yes

Abstract

Colchicine is the mainstay of treatment for familial Mediterranean fever. We investigated the frequency of leukopenia in 213 patients with familial Mediterranean fever treated with standard doses of colchicine (0.5-2.0 mg/day). We found that 23 patients (10.8%) had reversible leukopenia, 3 moderate, and none severe and that their rate of infections was not increased.