Colchicine and Leukopenia: Clinical Implications

Sag E. , Bayindir Y., Adiguzel A., Demir S., Bilginer Y., Aytac Ş. S. , ...More

JOURNAL OF PEDIATRICS, vol.224, pp.166-171, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 224
  • Publication Date: 2020
  • Doi Number: 10.1016/j.jpeds.2020.03.065
  • Title of Journal : JOURNAL OF PEDIATRICS
  • Page Numbers: pp.166-171


Colchicine is the mainstay of treatment for familial Mediterranean fever. We investigated the frequency of leukopenia in 213 patients with familial Mediterranean fever treated with standard doses of colchicine (0.5-2.0 mg/day). We found that 23 patients (10.8%) had reversible leukopenia, 3 moderate, and none severe and that their rate of infections was not increased.