Does Defective Apoptosis Play A Role in Cystic Fibrosis Lung Disease?

Yalcin E., TALİM B., Ozcelik U., DOĞRU ERSÖZ D., Cobanoglu N., Pekcan S., ...More

ARCHIVES OF MEDICAL RESEARCH, vol.40, no.7, pp.561-564, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 7
  • Publication Date: 2009
  • Doi Number: 10.1016/j.arcmed.2009.07.005
  • Journal Name: ARCHIVES OF MEDICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.561-564
  • Keywords: Apoptosis, Bronchiectasis, Bronchopneumonia, Cystic fibrosis, Lung, TRANSMEMBRANE CONDUCTANCE REGULATOR, RESPIRATORY EPITHELIAL-CELLS, EXPRESSION, INDUCTION, DNA, FAS
  • Hacettepe University Affiliated: Yes

Abstract

Background and Aims. Although apoptotic dysfunction has recently been suggested in cystic fibrosis (CF), there are few studies reported concerning apoptosis in CF with controversial results. The aim of this study was to investigate apoptosis in CF human lung tissues and compare with non-CF bronchiectatic and normal healthy lung tissues. We also investigated the relation between apoptosis and histopathological features of tissues and microbiological factors influencing apoptosis.