Combination of Metformin and Dichloroacetate Inhibits Proliferation and Induce Intrinsic Pathway of Apoptosis in PC-3 Human Prostate Cancer Cells

Kiliccioglu I., KONAÇ E., Albayrak G., Donmez C., Bilen C. Y.

GAZI MEDICAL JOURNAL, vol.26, pp.212-214, 2015 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 26
  • Publication Date: 2015
  • Doi Number: 10.12996/gmj.2015.65
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.212-214
  • Hacettepe University Affiliated: Yes


Objective: Prostate cancer is one of the most common cancers in men and is the second leading cause of male cancer deaths after lung cancer. Activation of apoptosis is an important process to overcome prostate cancer. In this study, we investigated the synergistic anti-proliferative and apoptotic effects of metformin and dichloroacetate (DCA) in human prostate cancer cell line PC-3.