Quartz Crystal Microbalance-Based Aptasensors for Medical Diagnosis

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MICROMACHINES, vol.13, no.9, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 13 Issue: 9
  • Publication Date: 2022
  • Doi Number: 10.3390/mi13091441
  • Journal Name: MICROMACHINES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aerospace Database, Communication Abstracts, Compendex, INSPEC, Metadex, Directory of Open Access Journals, Civil Engineering Abstracts
  • Keywords: aptamer, aptasensor, biosensor, label-free detection, diagnosis, medical applications, quartz crystal microbalance, SURFACE-PLASMON RESONANCE, LABEL-FREE DETECTION, SENSITIVE DETECTION, RAPID DETECTION, QCM APTASENSOR, IN-VITRO, APTAMER, BIOSENSOR, NANOPARTICLES, SENSOR
  • Hacettepe University Affiliated: Yes


Aptamers are important materials for the specific determination of different disease-related biomarkers. Several methods have been enhanced to transform selected target molecule-specific aptamer bindings into measurable signals. A number of specific aptamer-based biosensors have been designed for potential applications in clinical diagnostics. Various methods in combination with a wide variety of nano-scale materials have been employed to develop aptamer-based biosensors to further increase sensitivity and detection limit for related target molecules. In this critical review, we highlight the advantages of aptamers as biorecognition elements in biosensors for target biomolecules. In recent years, it has been demonstrated that electrode material plays an important role in obtaining quick, label-free, simple, stable, and sensitive detection in biological analysis using piezoelectric devices. For this reason, we review the recent progress in growth of aptamer-based QCM biosensors for medical diagnoses, including virus, bacteria, cell, protein, and disease biomarker detection.