Assessment of the relationship between polysomnography parameters and plasma malondialdehyde levels in patients with obstructive sleep apnea

Savas O., SÜSLÜ A. E., LAY İ., ÖZER S.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, vol.276, no.12, pp.3533-3538, 2019 (SCI-Expanded) identifier identifier identifier


Purpose The relationship of plasma malondialdehyde (MDA) with major parameters of PSG was investigated to find out if there was a correlation between these variables. Methods Polysomnograms were done on a total of 37 adults who do not have a history of any systemic illness, smoking, and supplement use. Plasma MDA measurements and their relationship with PSG parameters were analyzed. Results The mean MDA concentrations in patients with lower AHI values were also lower than those in the patients with higher AHI (p < 0.001). Higher predominance of apnea in patients with similar AHI values, longer mean apnea durations, O-2 saturation dips to < 90%, and higher ODI values predicted higher plasma MDA concentrations. Conclusions Higher oxidative stress measurements predicted more severe clinical picture. These findings show that oxidative stress measurement with MDA may provide a simple tool to screen patients for OSA and help select them for PSG study appropriately, if indicated