Apolipoprotein E gene polymorphism in renal transplant recipients: effects on lipid metabolism, atherosclerosis and allograft function


Kahraman S., Kiykim A., Altun B., Genctoy G., Arici M., Gulsun M., ...Daha Fazla

CLINICAL TRANSPLANTATION, cilt.18, ss.288-294, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 18 Konu: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1111/j.1399-0012.2004.00162.x
  • Dergi Adı: CLINICAL TRANSPLANTATION
  • Sayfa Sayıları: ss.288-294

Özet

Introduction: Atherosclerosis is a serious complication and leading cause of mortality in renal transplant recipients (RTRs). Hyperlipidemia may be associated with progression of renal disease and chronic allograft dysfunction. Similarities in the pathogenesis of glomerulosclerosis and atherosclerosis have been proposed. Apolipoprotein (apo) E gene code forms three major isoforms (E2, E3, and E4) with variable effects on lipid metabolism.