Apolipoprotein E gene polymorphism in renal transplant recipients: effects on lipid metabolism, atherosclerosis and allograft function


Kahraman S., Kiykim A., Altun B., Genctoy G., Arici M., Gulsun M., ...More

CLINICAL TRANSPLANTATION, vol.18, no.3, pp.288-294, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 3
  • Publication Date: 2004
  • Doi Number: 10.1111/j.1399-0012.2004.00162.x
  • Title of Journal : CLINICAL TRANSPLANTATION
  • Page Numbers: pp.288-294

Abstract

Introduction: Atherosclerosis is a serious complication and leading cause of mortality in renal transplant recipients (RTRs). Hyperlipidemia may be associated with progression of renal disease and chronic allograft dysfunction. Similarities in the pathogenesis of glomerulosclerosis and atherosclerosis have been proposed. Apolipoprotein (apo) E gene code forms three major isoforms (E2, E3, and E4) with variable effects on lipid metabolism.