Apolipoprotein E gene polymorphism in renal transplant recipients: effects on lipid metabolism, atherosclerosis and allograft function

Kahraman, S; Kiykim, AA; Altun, B; Genctoy, G; Arici, M; Gulsun, M; Erdem, Y; Yasavul, U; Turgan, C; Caglar, S

doi:10.1111/j.1399-0012.2004.00162.x

Apolipoprotein E gene polymorphism in renal transplant recipients: effects on lipid metabolism, atherosclerosis and allograft function

Kahraman S., Kiykim A., Altun B., Genctoy G., Arici M., Gulsun M., ...Daha Fazla

CLINICAL TRANSPLANTATION, cilt.18, sa.3, ss.288-294, 2004 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 18 Sayı: 3
Basım Tarihi: 2004
Doi Numarası: 10.1111/j.1399-0012.2004.00162.x
Dergi Adı: CLINICAL TRANSPLANTATION
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.288-294
Hacettepe Üniversitesi Adresli: Hayır

Özet

Introduction: Atherosclerosis is a serious complication and leading cause of mortality in renal transplant recipients (RTRs). Hyperlipidemia may be associated with progression of renal disease and chronic allograft dysfunction. Similarities in the pathogenesis of glomerulosclerosis and atherosclerosis have been proposed. Apolipoprotein (apo) E gene code forms three major isoforms (E2, E3, and E4) with variable effects on lipid metabolism.