One factor affecting teachers' workingconditions and students' academic success is the school principals' innovative work behavior. Researchers have increasingly focused on this issue in recent years. Previous studies show that principals' entrepreneurship and self-efficacy are essential factors in innovative work behavior. However, the holistic view of the effects of the principals' entrepreneurship and self-efficacy on their innovative work behavior has been neglected in these studies. Therefore, in the present study, we explored the direct and indirect relationships among principals' innovative work behavior, entrepreneurship, and self-efficacy through the developed model. We collected the study data from 411 principals working in Trabzon city in Turkiye. Finally, we tested the results of our model with bootstrapping technique. The findings show that the principals' entrepreneurship is a significant mediator between principals' self-efficacy and innovative work behavior. This finding contributes to the literature on the antecedents of innovative work behavior. At the end of our study, we made recommendations to policy-makers and principals based on the findings.