THE ROLE OF THE COMPLEMENT SYSTEM IN ALZHEIMER’S DISEASE ALZHEİMER HASTALIĞINDA KOMPLEMAN SİSTEMİN ROLÜ


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Yi̇Rün A., Erdemli̇ Köse S. B., ERKEKOĞLU Ü. P.

Ankara Universitesi Eczacilik Fakultesi Dergisi, vol.48, no.1, 2023 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.33483/jfpau.1337722
  • Journal Name: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Journal Indexes: Scopus, Central & Eastern European Academic Source (CEEAS), EMBASE, TR DİZİN (ULAKBİM)
  • Keywords: Alzheimer’s disease, central nervous system, complement system, immune system, neurodegeneration
  • Hacettepe University Affiliated: Yes

Abstract

Objective: Immune system is a system that defends the body against infections, reacts to foreign substances, and protects the organism in conditions such as illness. The central nervous system has a unique structure that differs from peripheral organs in terms of immune responses. Extensive research in recent years has shown that there is a complex interaction between the brain and immune system. Brain immune system is a complex system consisting of a number of cellular and molecular mechanisms within the central nervous system and a set of structures in which immune cells and molecules take place. It is known that chronic inflammation in the brain may play an important role in progressive neuron death in many neurodegenerative diseases. Alzheimer's disease, which has been affecting the elderly population, especially women in recent years, is a progressive, neurodegenerative disease characterized by problems related to short-term memory, cognition and difficulties in daily living activities. Alzheimer's disease occurs with a complex mechanism thought to include genetic, immune and environmental factors. There is no definite cure for this disease and the drugs used only delay the symptoms. The complement system is part of the innate immune system. This system has three different activating pathways and results in the formation of a membrane attack complex that ultimately causes target cell lysis. Result and Discussion: In this review, we aimed to share information about the functioning of the complement system in the central nervous system and how it contributes to chronic neuroinflammation that leads to neurodegenerative disorders such as Alzheimer’s disease.