Inadequate Brain Glycogen or Sleep Increases Spreading Depression Susceptibility

KILIÇ K., Karatas H. , DONMEZ-DEMİR B., Eren-Kocak E. , Gursoy-Ozdemir Y., Can A., ...More

ANNALS OF NEUROLOGY, vol.83, no.1, pp.61-73, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 83 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1002/ana.25122
  • Title of Journal : ANNALS OF NEUROLOGY
  • Page Numbers: pp.61-73


Objective: Glycogen in astrocyte processes contributes to maintenance of low extracellular glutamate and K+ concentrations around excitatory synapses. Sleep deprivation (SD), a common migraine trigger, induces transcriptional changes in astrocytes, reducing glycogen breakdown. We hypothesize that when glycogen utilization cannot match synaptic energy demand, extracellular K+ can rise to levels that activate neuronal pannexin-1 channels and downstream inflammatory pathway, which might be one of the mechanisms initiating migraine headaches.