Inadequate Brain Glycogen or Sleep Increases Spreading Depression Susceptibility
ANNALS OF NEUROLOGY, vol.83, no.1, pp.61-73, 2018 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 83 Issue: 1
- Publication Date: 2018
- Doi Number: 10.1002/ana.25122
- Journal Name: ANNALS OF NEUROLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.61-73
- Open Archive Collection: AVESIS Open Access Collection
- Hacettepe University Affiliated: Yes
Abstract
Objective: Glycogen in astrocyte processes contributes to maintenance of low extracellular glutamate and K+ concentrations around excitatory synapses. Sleep deprivation (SD), a common migraine trigger, induces transcriptional changes in astrocytes, reducing glycogen breakdown. We hypothesize that when glycogen utilization cannot match synaptic energy demand, extracellular K+ can rise to levels that activate neuronal pannexin-1 channels and downstream inflammatory pathway, which might be one of the mechanisms initiating migraine headaches.