In vitro assessment of cytotoxic, apoptotic and genotoxic effects of metformin

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Sariaydin T., ÇAL T., AYDIN DİLSİZ S., CANPINAR H., ÜNDEĞER BUCURGAT Ü.

ISTANBUL JOURNAL OF PHARMACY, cilt.51, sa.2, ss.167-174, 2021 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.26650/istanbuljpharm.2021.0079
  • Dergi Adı: ISTANBUL JOURNAL OF PHARMACY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.167-174
  • Anahtar Kelimeler: Metformin, genotoxicity, apoptosis, HepG2 cells, HeLa cells, ANTIDIABETIC DRUG METFORMIN, HEPATOCELLULAR-CARCINOMA, DNA-DAMAGE, CANCER, CELLS, PROSTATE, GROWTH, VIVO
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background and Aims: Recent studies have shown the anticancer properties of metformin, which is widely used in diabetes mellitus. The possible mechanisms of anticancer effects of metformin have not been fully elucidated. We aimed to investigate the cytotoxic, genotoxic, and apoptotic effects of metformin in HepG2 and HeLa cells.