In vitro assessment of cytotoxic, apoptotic and genotoxic effects of metformin


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Sariaydin T., ÇAL T., AYDIN DİLSİZ S., CANPINAR H., ÜNDEĞER BUCURGAT Ü.

ISTANBUL JOURNAL OF PHARMACY, vol.51, no.2, pp.167-174, 2021 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.26650/istanbuljpharm.2021.0079
  • Journal Name: ISTANBUL JOURNAL OF PHARMACY
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.167-174
  • Keywords: Metformin, genotoxicity, apoptosis, HepG2 cells, HeLa cells, ANTIDIABETIC DRUG METFORMIN, HEPATOCELLULAR-CARCINOMA, DNA-DAMAGE, CANCER, CELLS, PROSTATE, GROWTH, VIVO
  • Hacettepe University Affiliated: Yes

Abstract

Background and Aims: Recent studies have shown the anticancer properties of metformin, which is widely used in diabetes mellitus. The possible mechanisms of anticancer effects of metformin have not been fully elucidated. We aimed to investigate the cytotoxic, genotoxic, and apoptotic effects of metformin in HepG2 and HeLa cells.