Measurement of in vitro phagocytic activity using functional groups carrying monodisperse poly(glycidyl methacrylate) microspheres in rat blood

Ulusoy, AH; Onur, MA

doi:10.1163/156856203322553509

Measurement of in vitro phagocytic activity using functional groups carrying monodisperse poly(glycidyl methacrylate) microspheres in rat blood

Atıf İçin Kopyala

Ulusoy A., Onur M.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, cilt.14, sa.11, ss.1299-1310, 2003 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 14 Sayı: 11
Basım Tarihi: 2003
Doi Numarası: 10.1163/156856203322553509
Dergi Adı: JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1299-1310
Hacettepe Üniversitesi Adresli: Hayır

Özet

Phagocytic activity of monocyte and neutrophil leukocytes in rat blood was investigated C using monodisperse poly(glycidyl methacrylate) (poly(GMA)) microspheres. Interactions of monocyte and neutrophil leukocytes with plain poly(GMA), charged poly(GMA)-NH2 and biomodified poly(GMA) (poly(GMA)-albumin and opsonized poly(GMA)) was studied as a function of time. Here we report the cellular phagocytosis rate of particles and the total internalised particle amount. Phagocytes showed higher phagocytic activity for poly(GMA) microspheres carrying functional groups versus plain poly(GMA) particles. Phagocytic activity was the highest for opsonized poly(GMA) microspheres (P < 0.05).