Evaluation of Serum Vitamin D Levels in Adolescents with Pubertal Gynecomastia

Kizilkan M. P. , AKGÜL S. , Akbiyik F. , DERMAN O. , KANBUR N.

BREAST CARE, cilt.11, sa.5, ss.333-337, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Konu: 5
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1159/000451074
  • Dergi Adı: BREAST CARE
  • Sayfa Sayıları: ss.333-337


Background: Since vitamin D has an inhibitory function on ductal morphogenesis of the pubertal mammary gland, it may have a role in the development of gynecomastia. The aim of this study was to determine the effect of vitamin D deficiency on the development of pubertal gynecomastia. Methods: Serum 25-hydroxyvitamin D (25D) levels in 50 adolescents with pubertal gynecomastia and 54 healthy controls between the ages of 11 and 17 years were compared. Results: Mean 25D level was 14.03 +/- 6.38 (5.0-32.5) ng/ml in the pubertal gynecomastia group and 15.19 +/- 6.49 (5.0-33.2) ng/ml in the control group (p = 0.361). According to the vitamin D status classification of the American Academy of Pediatrics, 66% of the pubertal gynecomastia group was found to be deficient and 14% were insufficient. In the control group these values were 53.7% and 29.6%, respectively (p = 0.158). Conclusion: From our results we hypothesize that, rather than low serum levels of 25D, a dysregulation of the vitamin D signal pathway, vitamin D metabolism or vitamin D storage within the mammary tissue might be the contributing factors to the development of gynecomastia. (C) 2016 S. Karger GmbH, Freiburg