Evaluation of Serum Vitamin D Levels in Adolescents with Pubertal Gynecomastia

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Kizilkan M. P., AKGÜL S., Akbiyik F., DERMAN O., KANBUR N.

BREAST CARE, vol.11, no.5, pp.333-337, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.1159/000451074
  • Journal Name: BREAST CARE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.333-337
  • Hacettepe University Affiliated: Yes


Background: Since vitamin D has an inhibitory function on ductal morphogenesis of the pubertal mammary gland, it may have a role in the development of gynecomastia. The aim of this study was to determine the effect of vitamin D deficiency on the development of pubertal gynecomastia. Methods: Serum 25-hydroxyvitamin D (25D) levels in 50 adolescents with pubertal gynecomastia and 54 healthy controls between the ages of 11 and 17 years were compared. Results: Mean 25D level was 14.03 +/- 6.38 (5.0-32.5) ng/ml in the pubertal gynecomastia group and 15.19 +/- 6.49 (5.0-33.2) ng/ml in the control group (p = 0.361). According to the vitamin D status classification of the American Academy of Pediatrics, 66% of the pubertal gynecomastia group was found to be deficient and 14% were insufficient. In the control group these values were 53.7% and 29.6%, respectively (p = 0.158). Conclusion: From our results we hypothesize that, rather than low serum levels of 25D, a dysregulation of the vitamin D signal pathway, vitamin D metabolism or vitamin D storage within the mammary tissue might be the contributing factors to the development of gynecomastia. (C) 2016 S. Karger GmbH, Freiburg