Mildly elevated lactate levels are associated with microcirculatory flow abnormalities and increased mortality: a microSOAP post hoc analysis

Vellinga, Namkje; Boerma, E.; Koopmans, Matty; Donati, Abele; Dubin, Arnaldo; Shapiro, Nathan; Pearse, Rupert; van der Voort, Peter; Dondorp, Arjen; Bafi, Tony; Fries, Michael; Akarsu-Ayazoglu, Tulin; Pranskunas, Andrius; Hollenberg, Steven; Balestra, Gianmarco; van Iterson, Mat; Sadaka, Farid; Minto, Gary; Aypar, Ulku; Hurtado, F.; Martinelli, Giampaolo; Payen, Didier; van Haren, Frank; Holley, Anthony; Gomez, Hernando; Mehta, Ravindra; Rodriguez, Alejandro; Ruiz, Carolina; Canales, Hector; Duranteau, Jacques; Spronk, Peter; Jhanji, Shaman; Hubble, Sheena; Chierego, Marialuisa; Jung, Christian; Martin, Daniel; Sorbara, Carlo; Bakker, Jan; Ince, Can

doi:10.1186/s13054-017-1842-7

Mildly elevated lactate levels are associated with microcirculatory flow abnormalities and increased mortality: a microSOAP post hoc analysis

Vellinga N. A. R., Boerma E. C., Koopmans M., Donati A., Dubin A., Shapiro N. I., ...More

CRITICAL CARE, vol.21, 2017 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 21
Publication Date: 2017
Doi Number: 10.1186/s13054-017-1842-7
Journal Name: CRITICAL CARE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Hacettepe University Affiliated: Yes

Abstract

Background: Mildly elevated lactate levels (i.e., 1-2 mmol/L) are increasingly recognized as a prognostic finding in critically ill patients. One of several possible underlying mechanisms, microcirculatory dysfunction, can be assessed at the bedside using sublingual direct in vivo microscopy. We aimed to evaluate the association between relative hyperlactatemia, microcirculatory flow, and outcome.