Gut-brain-microbiota axis: Antibiotics and functional gastrointestinal disorders

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KARAKAN T., ÖZKUL KOÇAK C., Akkol E. K., BİLİCİ S., Sobarzo-Sánchez E., Capasso R.

Nutrients, vol.13, no.2, pp.1-18, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 13 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.3390/nu13020389
  • Journal Name: Nutrients
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, CINAHL, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.1-18
  • Keywords: gut microbiota, gut microbiome, gut-brain axis, functional bowel disorders, irritable bowel syndrome, antibiotics, probiotics
  • Hacettepe University Affiliated: Yes


© 2021 by the authors. Licensee MDPI, Basel, Switzerland.Gut microbiota composition and function are major areas of research for functional gastrointestinal disorders. There is a connection between gastrointestinal tract and central nervous system and this is mediated by neurotransmitters, inflammatory cytokines, the vagus nerve and the hypothalamic-pituitary-adrenal axis. Functional gastrointestinal disorders are prevalent diseases af-fecting more than one third of the population. The etiology of these disorders is not clarified. Visceral hyperalgesia is the main hypothesis for explaining clinical symptoms, however gut-brain axis disorder is a new terminology for functional disorders. In this review, microbiota-gut-brain axis connection pathways and related disorders are discussed. Antibiotics are widely used in developed countries and recent evidence indicates antibiotic-induced dysbiosis as an important factor for functional disorders. Antibiotics exert negative effects on gut microbiota composition and functions. Antibiotic-induced dysbiosis is a major factor for occurrence of post-infectious irritable bowel syndrome. Cognitive and mood disorders are also frequent in functional gastrointestinal disorders. Animal and human trials show strong evidence for the causal relationship between gut microbiota and brain functions. Therapeutic implications of these newly defined pathogenic pathways are also discussed.