The effect of thymoquinone coating on adhesive properties of polypropylene mesh

Aydin O., Aydinuraz K., Agalar F., Sahiner I. T., Agalar C., BAYRAM C., ...More

BMC SURGERY, vol.17, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17
  • Publication Date: 2017
  • Doi Number: 10.1186/s12893-017-0239-5
  • Journal Name: BMC SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Thymoquinone, Intraabdominal adhesion, Polypropylene mesh, Incisional hernia, RANDOMIZED CONTROLLED-TRIAL, TERM-FOLLOW-UP, INCISIONAL HERNIA, NIGELLA-SATIVA, REPAIR, LEUKOCYTES, SUTURE, OIL
  • Hacettepe University Affiliated: Yes


Background: An incisional hernia is a common complication following abdominal surgery. Polypropylene mesh is frequently used in the repair of such defects and has nearly become the standard surgical treatment modality. Though they are very effective in reducing recurrence, mesh materials exhibit a strong stimulating effect for intraabdominal adhesion. The thymoquinone (TQ) extracted from Nigella sativa seeds has potential medical properties. TQ has antiinflammatory, antioxidant and antibacterial properties. The aim of this study is to coat polypropylene mesh with TQ in order to investigate the effect of surface modification on intraabdominal adhesions.