Alterations of Tear Film and Ocular Surface in Children with Type 1 Diabetes Mellitus

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İnanç M., Kızıltoprak H., Hekimoglu R., Tekin K., Özalkak S., Koç M., ...More

Ocular Immunology and Inflammation, 2019 (SCI-Expanded)

• Publication Type: Article / Article
• Publication Date: 2019
• Doi Number: 10.1080/09273948.2019.1571212
• Journal Name: Ocular Immunology and Inflammation
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Hacettepe University Affiliated: Yes

Abstract

Purpose: To investigate whether diabetes mellitus (DM) affects ocular surface of children with well-controlled type 1 DM.

Methods: Sixty-five diabetic patients and 55 age-matched controls enrolled to study. Detailed ocular surface assessment including, ocular surface disease index (OSDI) questionnaire, tear film break-up time (TBUT) analysis, Schirmer test, and conjunctival impression cytologic analysis were performed.

Results: Schirmer test and TBUT results were significantly lower in DM group than controls (p= 0.001, for all). OSDI scores of all participants were within normal range. Impression cytology analysis showed grade 0 changes in all participants and there was no difference between groups for goblet cell density (p > 0.05). The TBUT results were significantly associated with duration of DM (r = −0.309, p = 0.036).

Conclusion: Diabetic children without symptoms, signs, and definite diagnosis of dry eye still had lower TBUT and Schirmer test results than controls; however, impression cytology analysis was similar in both groups.