Disparities in healthcare in psoriatic arthritis: an analysis of 439 patients from 13 countries


Lucasson F., Kiltz U., KALYONCU U., Leung Y. Y. , Palominos P., Canete J., ...More

RMD OPEN, vol.8, no.1, 2022 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.1136/rmdopen-2021-002031
  • Journal Name: RMD OPEN
  • Journal Indexes: Science Citation Index Expanded, Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
  • Keywords: Arthritis, Psoriatic, Outcome Assessment, Health Care, Epidemiology, REPORTED OUTCOME MEASURE, LOW DISEASE-ACTIVITY, RHEUMATOID-ARTHRITIS, SOCIOECONOMIC DETERMINANTS, VALIDATION, SPONDYLOARTHRITIS, QUESTIONNAIRE, ENTHESITIS, REMISSION, MORTALITY

Abstract

Objectives Patient care can vary substantially by country. The objective was to explore differences in psoriatic arthritis (PsA) across countries for disease activity, impact and treatments. Methods A cross-sectional analysis of 13 countries from the Remission/Flare in PsA study (NCT03119805) of consecutive adult patients with definite PsA was performed. Countries were classified into tertiles by gross domestic product (GDP)/capita. Disease activity (Disease Activity in PsA, DAPSA and Minimal Disease Activity, MDA) and their components, disease impact (patient-reported outcomes) and biological disease-modifying antirheumatic drugs (bDMARDs) were analysed per country and compared between the three tertiles of GDP/capita by parametric and non-parametric tests. We also explored the percentage of patients with significant disease activity (DAPSA >14) and no ongoing bDMARD prescription. Results In 439 patients (50.6% male, mean age 52.3 years, mean disease duration 10.1 years), disease activity and disease impact were higher in the lowest GDP/capita countries. DAPSA remission and MDA were attained in the lowest tertile in 7.0% and 18.4% patients, vs 29.1% and 49.5% in the middle tertile and 16.8% and 41.3% in the high tertile, respectively (all p<0.001). bDMARDs use was similar in the tertiles (overall mean 61%). The overall rate of patients with DAPSA >14 and no bDMARDs was 18.5%, and was higher in lower GDP/capita countries (p=0.004). Conclusion PsA patients from countries with the lowest GDP/capita, despite similar use of bDMARDs, were more likely to have high disease activity and worse disease impact. There is a need for more equity in healthcare.