Research Information System
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2025 (SCI-Expanded)
Advanced approaches such as biomimetic materials and stimulus-responsive systems that mimic complex biological processes in the body play an important role in the development of natural healing mechanisms. In this study, silica nanoparticles modified with magnetic nanoparticles triggered by magnetic field were synthesized by two methods as a multifunctional bone scaffold supplement. The nanoparticles were characterized by FIB-SEM, FT-IR, BET, DLS, VSM and zeta potential measurements. BSA model protein was loaded into magnetic silica nanoparticles and a loading capacity of 464.74 mg/g was obtained. Protein release studies were performed using an in-house Magnetic Field Triggered Release System (MFTRS), developed for greater control over magnetic nanoparticles. When the magnetic field was applied for 2 and 5 min, BSA release at 48 h was 58.95 +/- 3.38 % and 74.03 +/- 3.09 %, respectively. Without magnetic field, protein release was only 19.79 +/- 3.90 % at 48 h. Furthermore, the release kinetics were analyzed using the Higuchi and Korsmeyer-Peppas models to understand the release mechanisms. The obtained results show that the magnetic field triggers protein release and the release rates increase as the field duration increases, emphasizing the potential of magnetic field-triggered nanoparticles in controlled protein delivery systems.