Alterations in Hepatic Gene Expressions of CYP2C11, CYP2C6V, and CYP2D3 Enzymes in Endotoxemic Rats

Ozer E. K., Kurtgoz S., Goktas M. T., Karaca R. O., Caliskan M., Bariskaner H., ...More

JOURNAL OF MEDICAL AND SURGICAL INTENSIVE CARE MEDICINE, vol.8, no.2, pp.50-53, 2017 (ESCI) identifier identifier


Objective: Human cytochrome P450 2C9 (CYP2C9), CYP2C19, and CYP2D6 (corresponding to rat CYP2C11, CYP2C6V, and CYP2D3, respectively) are the major enzymes responsible for the metabolism of a wide range of drugs and chemicals. Changes in CYP efficiency are associated with disease susceptibility that can lead to drug toxicity or ineffective therapy. We aimed to examine the effects of lipopolysaccharide (LPS)-induced endotoxemia on gene expressions of hepatic microsomal CYP enzymes in rats.