Phenylethanoid glycosides from <i>Globularia trichosantha</i>

Çalis I., Kirmizibekmez H., Rüegger H., Sticher O.

JOURNAL OF NATURAL PRODUCTS, no.8, pp.1165-1168, 1999 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 1999
  • Doi Number: 10.1021/np9900526
  • Journal Name: JOURNAL OF NATURAL PRODUCTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.1165-1168
  • Hacettepe University Affiliated: Yes

Abstract

Five phenylethanoid glycosides, crenatoside (= oraposide) (1), verbascoside (= acteoside) (2), trichosanthoside A (3), rossicaside A (4), and trichosanthoside B (5), were isolated from the aerial parts of Globularia trichosantha. Compounds 3 and 5 are new natural compounds, and their structures were established as 3, 4-dihydroxy-beta-phenylethoxy-O-beta-D-xylopyranosyl-(1-->4)alpha-L-rhamnopyranosyl-(1-->3)-4-O-caffeoyl-beta-D-glucopyranoside and 3,4-dihydroxy-beta-phenylethoxy-O-[beta-D-xylopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->3)]-[beta-D-xylopyfanosyl-(1-->6)]-4-O-caffeoyl-beta-D-glucopyranoside, respectively. The structures of all compounds were established by spectral evidence. Compounds 1-5 also demonstrated scavenging properties toward the 2,2-diphenyl-1-picrylhydrazyl radical in TLC autographic assays.