Liposomal Nanocarriers for Tumor Imaging

Erdogan S.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, vol.5, no.2, pp.141-150, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 5 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1166/jbn.2009.1016
  • Journal Name: JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.141-150
  • Keywords: Liposome, Tumor Imaging, Scintigraphic Imaging, Computed Tomography (CT), Magnetic Resonance Imaging (MRI), Ultrasonography, THERMOSENSITIVE PARAMAGNETIC LIPOSOMES, STERICALLY STABILIZED LIPOSOMES, EFFECTIVE GENE DELIVERY, CONTRAST AGENT, IN-VITRO, POLYETHYLENE-GLYCOL, ULTRASOUND PHYSICS, DRUG-DELIVERY, PLASMID DNA, BLOOD-POOL
  • Hacettepe University Affiliated: Yes

Abstract

Currently used imaging modalities such as scintigraphy, computed tomography, magnetic resonance imaging and ultrasonography require the sufficient intensity of a corresponding signal from an area of interest to differentiate this area from the surrounding tissues. Targeting of various reporter moieties directly to the specific organs, tissues or tumors provide the highest dose of drug directly where it is needed. Many different types of nanoparticles are currently being studied for applications in nanomedicine. Among particulate drug carriers, liposomes are one of the most extensively studied and possess the most suitable characteristics for encapsulation of many drugs, genes, and diagnostic (imaging) agents. Among the many potential targets for such nanocarriers, tumors have been most often investigated. This review attempts to summarize the currently available information regarding liposomal nanocarriers for cancer imaging.