CYP1A1 gene polymorphism and risk of epithelial ovarian neoplasm

Aktas D., Guney I., Alikasifoglu M., Yuce K., Tuncbilek E., Ayhan A.

GYNECOLOGIC ONCOLOGY, cilt.86, sa.2, ss.124-128, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 86 Sayı: 2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1006/gyno.2002.6720
  • Dergi Adı: GYNECOLOGIC ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.124-128
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objective. Gene-environment interactions have been the focus of a number of recent studies of the occurrence of human cancers, and an association between the risk and the CYP1A1*3 polymorphism has been noticed for several cancers. Previous studies suggest that estrogens are involved in the etiology of ovarian cancer. The cytochrome P450 1A1 (CYP1A1) gene polymorphism may play role in the development of epithelial ovarian neoplasm by detoxification of polycyclic hydrocarbons and other compounds and the concentration of estrogens and their metabolites. Therefore, we assessed the association of CYP1A1 gene polymorphism in patients with epithelial ovarian neoplasm in the Turkish populations through a case-control study.