Serum resistin and high sensitive CRP levels in patients with subclinical hypothyroidism before and after L-thyroxine therapy

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Aksoy D. Y., Cinar N., Harmanci A., Karakaya J., Yildiz B. O., Usman A., ...More

MEDICAL SCIENCE MONITOR, vol.19, pp.210-215, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19
  • Publication Date: 2013
  • Doi Number: 10.12659/msm.883847
  • Journal Name: MEDICAL SCIENCE MONITOR
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.210-215
  • Keywords: resistin, high-sensitive-CRP, subclinical hypothyroidism, C-REACTIVE PROTEIN, CARDIOVASCULAR RISK-FACTORS, LOW-GRADE INFLAMMATION, NECROSIS-FACTOR-ALPHA, INSULIN-RESISTANCE, THYROID-FUNCTION, ADIPONECTIN, OBESITY, LEPTIN, EXPRESSION
  • Hacettepe University Affiliated: Yes

Abstract

Background: Subclinical hypothyroidism (SH) is defined by increased thyrotropin (TSH) and normal free thyroxine (fT4) and free triiodothyronine (fT3) levels. Resistin is secreted from adipose tissue and is reported to be associated with insulin resistance and/or inflammation. High sensitive CRP (hs-CRP) is a reliable marker of inflammation. Data related to levels of resistin and hs-CRP in SH and the effect of L-thyroxine treatment on those is limited. We aimed to determine the levels of resistin and hs-CRP in women with SH, and potential effects of L-thyroxine therapy on those levels.