Eosinophilic myositis in calpainopathy: Could immunosuppression of the eosinophilic myositis alter the early natural course of the dystrophic disease?


Oflazer P. S. , Gundesli H., ZORLUDEMİR S., Sabuncu T., Dincer P.

NEUROMUSCULAR DISORDERS, vol.19, no.4, pp.261-263, 2009 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 4
  • Publication Date: 2009
  • Doi Number: 10.1016/j.nmd.2009.01.010
  • Journal Name: NEUROMUSCULAR DISORDERS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.261-263
  • Keywords: Calpainopathy, LGMD 2A, Eosinophilic myositis, Muscular dystrophy, MUSCULAR-DYSTROPHY, CAPN3 MUTATIONS, INFLAMMATION, CALPAIN-3, PROTEIN, MUSCLE, DYSFERLIN

Abstract

An 11-year-old girl with a calpain-3 gene (CAPN-3) mutation and eosinophilic myositis on muscle biopsy had high serum CK levels and eosinophil counts which showed spontaneous fluctuations. After commencement of immunosuppressive therapy reciprocal changes occured in response to alterations in closes of the medications. Subacutely evolving and spreading muscle weakness developed during tapering of the immunosuppressive medications.