Magnesium sulfate treatment decreases caspase-3 activity after experimental spinal cord injury in rats
SURGICAL NEUROLOGY, vol.64, pp.17-21, 2005 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 64
- Publication Date: 2005
- Doi Number: 10.1016/j.surneu.2005.07.058
- Journal Name: SURGICAL NEUROLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.17-21
- Hacettepe University Affiliated: No
Abstract
Background: Apoptosis has increasingly been considered as an important factor in secondary injury after spinal cord injury (SCI). Manifestation of apoptotic cell death process involves activation of the caspase-3 apoptotic cascade. The aim of the study was to demonstrate the effect of magnesium sulfate on caspase-3 activity and to compare its effectiveness with methylprednisolone after acute SCI.