Magnesium sulfate treatment decreases caspase-3 activity after experimental spinal cord injury in rats

Solaroglu I., Kaptanoglu E., Okutan O., Beskonakli E., Attar A., Kilinc K.

SURGICAL NEUROLOGY, vol.64, pp.17-21, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64
  • Publication Date: 2005
  • Doi Number: 10.1016/j.surneu.2005.07.058
  • Journal Name: SURGICAL NEUROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.17-21
  • Hacettepe University Affiliated: No

Abstract

Background: Apoptosis has increasingly been considered as an important factor in secondary injury after spinal cord injury (SCI). Manifestation of apoptotic cell death process involves activation of the caspase-3 apoptotic cascade. The aim of the study was to demonstrate the effect of magnesium sulfate on caspase-3 activity and to compare its effectiveness with methylprednisolone after acute SCI.