Effects of Low-Dose Doxycycline and Bisphosphonate Clodronate on Alveolar Bone Loss and Gingival Levels of Matrix Metalloproteinase-9 and Interleukin-1 beta in Rats With Diabetes: A Histomorphometric and Immunohistochemical Study

Ozdemir S. P., Kurti B., Tuter G., Bozkurt S., Gultekin S. E., Senguven B., ...Daha Fazla

JOURNAL OF PERIODONTOLOGY, cilt.83, sa.9, ss.1172-1182, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 83 Sayı: 9
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1902/jop.2012.110459
  • Dergi Adı: JOURNAL OF PERIODONTOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1172-1182
  • Anahtar Kelimeler: Bisphosphonate, cytokines, diabetes mellitus, doxycycline, matrix metalloproteinases, periodontium, ENDOTOXIN-INDUCED PERIODONTITIS, MATRIX METALLOPROTEINASES, PAGETS-DISEASE, OSTEONECROSIS, MELLITUS, JAW, ALENDRONATE, RESORPTION, EXPRESSION, EFFICACY
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Bisphosphonates (BPs) and low-dose doxycycline (LDD) have been shown to inhibit bone resorption and to improve the levels of proinflammatory mediators and destructive enzymes in gingival tissues, respectively. The purpose of this study is to evaluate the effect of mono and combined BP clodronate and LDD therapies in reducing gingival levels of matrix metalloproteinase-9 (MMP-9), interleukin-1 beta (IL-1 beta), and alveolar bone loss in rats with diabetes.