Effects of Low-Dose Doxycycline and Bisphosphonate Clodronate on Alveolar Bone Loss and Gingival Levels of Matrix Metalloproteinase-9 and Interleukin-1 beta in Rats With Diabetes: A Histomorphometric and Immunohistochemical Study

Ozdemir S. P., Kurti B., Tuter G., Bozkurt S., Gultekin S. E., Senguven B., ...More

JOURNAL OF PERIODONTOLOGY, vol.83, no.9, pp.1172-1182, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 83 Issue: 9
  • Publication Date: 2012
  • Doi Number: 10.1902/jop.2012.110459
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1172-1182
  • Keywords: Bisphosphonate, cytokines, diabetes mellitus, doxycycline, matrix metalloproteinases, periodontium, ENDOTOXIN-INDUCED PERIODONTITIS, MATRIX METALLOPROTEINASES, PAGETS-DISEASE, OSTEONECROSIS, MELLITUS, JAW, ALENDRONATE, RESORPTION, EXPRESSION, EFFICACY
  • Hacettepe University Affiliated: Yes


Background: Bisphosphonates (BPs) and low-dose doxycycline (LDD) have been shown to inhibit bone resorption and to improve the levels of proinflammatory mediators and destructive enzymes in gingival tissues, respectively. The purpose of this study is to evaluate the effect of mono and combined BP clodronate and LDD therapies in reducing gingival levels of matrix metalloproteinase-9 (MMP-9), interleukin-1 beta (IL-1 beta), and alveolar bone loss in rats with diabetes.