Neuroprotective Potential of Biflavone Ginkgetin: A Review

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Tatlı Çankaya İ. İ., Devkota H. P., Zengin G., Šamec D.

Life, vol.13, no.2, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 13 Issue: 2
  • Publication Date: 2023
  • Doi Number: 10.3390/life13020562
  • Journal Name: Life
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Alzheimer’s disease, biflavonoids, ginkgetin, ginkgo, neuroprotection
  • Hacettepe University Affiliated: Yes


Neurological disorders are becoming more common, and there is an intense search for molecules that can help treat them. Several natural components, especially those from the flavonoid group, have shown promising results. Ginkgetin is the first known biflavonoid, a flavonoid dimer isolated from ginkgo (Ginkgo biloba L.). Later, its occurrence was discovered in more than 20 different plant species, most of which are known for their use in traditional medicine. Herein we have summarized the data on the neuroprotective potential of ginkgetin. There is evidence of protection against neuronal damage caused by ischemic strokes, neurotumors, Alzheimer’s disease (AD), and Parkinson’s disease (PD). Beneficial effects in ischemic strokes have been demonstrated in animal studies in which injection of ginkgetin before or after onset of the stoke showed protection from neuronal damage. AD protection has been the most studied to date. Possible mechanisms include inhibition of reactive oxygen species, inhibition of β-secretase, inhibition of Aβ fibril formation, amelioration of inflammation, and antimicrobial activity. Ginkgetin has also shown positive effects on the relief of PD symptoms in animal studies. Most of the available data are from in vitro or in vivo animal studies, where ginkgetin showed promising results, and further clinical studies should be conducted.