Pancreatic Endocrine and Exocrine Function in Children following Near-Total Pancreatectomy for Diffuse Congenital Hyperinsulinism

Arya V. B. , Senniappan S., Demirbilek H., Alam S., Flanagan S. E. , Ellard S., ...More

PLOS ONE, vol.9, no.5, 2014 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 5
  • Publication Date: 2014
  • Doi Number: 10.1371/journal.pone.0098054
  • Journal Name: PLOS ONE
  • Journal Indexes: Science Citation Index Expanded, Scopus


Context: Congenital hyperinsulinism (CHI), the commonest cause of persistent hypoglycaemia, has two main histological subtypes: diffuse and focal. Diffuse CHI, if medically unresponsive, is managed with near-total pancreatectomy. Post-pancreatectomy, in addition to persistent hypoglycaemia, there is a very high risk of diabetes mellitus and pancreatic exocrine insufficiency.