Pancreatic Endocrine and Exocrine Function in Children following Near-Total Pancreatectomy for Diffuse Congenital Hyperinsulinism


Arya V. B. , Senniappan S., Demirbilek H. , Alam S., Flanagan S. E. , Ellard S., ...Daha Fazla

PLOS ONE, cilt.9, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Context: Congenital hyperinsulinism (CHI), the commonest cause of persistent hypoglycaemia, has two main histological subtypes: diffuse and focal. Diffuse CHI, if medically unresponsive, is managed with near-total pancreatectomy. Post-pancreatectomy, in addition to persistent hypoglycaemia, there is a very high risk of diabetes mellitus and pancreatic exocrine insufficiency.