Metal triflates-catalyzed conjugate addition of homochiral Pyrroles to alpha,beta-unsaturated esters


Unaleroglu C. , Temelli B. , Demir A. s.

SYNTHESIS-STUTTGART, ss.2574-2578, 2004 (SCI İndekslerine Giren Dergi) identifier identifier

  • Basım Tarihi: 2004
  • Doi Numarası: 10.1055/s-2004-831195
  • Dergi Adı: SYNTHESIS-STUTTGART
  • Sayfa Sayıları: ss.2574-2578

Özet

The Friedel-Crafts reaction of homochiral pyrrole derivatives with alpha,beta-unsaturated esters catalyzed by metal triflates furnished conjugate addition products. The best yields were obtained by using yttrium triflate and methyl 4-phenyl-2-oxobut-3-enoate (2a). The addition worked regioselectively at C-5 of pyrrole. The diastereoisomers were separated by column chromatography.