SYNTHESIS-STUTTGART, no.15, pp.2574-2578, 2004 (SCI-Expanded)
Article / Article
Science Citation Index Expanded (SCI-EXPANDED), Scopus
homochiral pyrroles, metal triflates, conjugate addition, Friedel-Crafts reaction, pyrroles, INTRAMOLECULAR CARBENOID REACTIONS, DERIVATIVES, ALKYLATION, KETOESTERS
Hacettepe University Affiliated:
The Friedel-Crafts reaction of homochiral pyrrole derivatives with alpha,beta-unsaturated esters catalyzed by metal triflates furnished conjugate addition products. The best yields were obtained by using yttrium triflate and methyl 4-phenyl-2-oxobut-3-enoate (2a). The addition worked regioselectively at C-5 of pyrrole. The diastereoisomers were separated by column chromatography.