Metal triflates-catalyzed conjugate addition of homochiral Pyrroles to alpha,beta-unsaturated esters
SYNTHESIS-STUTTGART, sa.15, ss.2574-2578, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2004
- Doi Numarası: 10.1055/s-2004-831195
- Dergi Adı: SYNTHESIS-STUTTGART
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.2574-2578
- Anahtar Kelimeler: homochiral pyrroles, metal triflates, conjugate addition, Friedel-Crafts reaction, pyrroles, INTRAMOLECULAR CARBENOID REACTIONS, DERIVATIVES, ALKYLATION, KETOESTERS
- Hacettepe Üniversitesi Adresli: Evet
Özet
The Friedel-Crafts reaction of homochiral pyrrole derivatives with alpha,beta-unsaturated esters catalyzed by metal triflates furnished conjugate addition products. The best yields were obtained by using yttrium triflate and methyl 4-phenyl-2-oxobut-3-enoate (2a). The addition worked regioselectively at C-5 of pyrrole. The diastereoisomers were separated by column chromatography.