Hematopoietic Stem Cell Transplantation for Patients with Paroxysmal Nocturnal Hemoglobinuria with or without Aplastic Anemia: A Multicenter Turkish Experience

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Yilmaz F., SOYER N., Seval G. C., Bozdag S. C., TOPÇUOĞLU P., ÜNAL A., ...Daha Fazla

TURKISH JOURNAL OF HEMATOLOGY, cilt.38, sa.3, ss.195-203, 2021 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.4274/tjh.galenos.2021.2021.0105
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.195-203
  • Anahtar Kelimeler: Paroxysmal nocturnal hemoglobinuria, Transplantation, Allogeneic stem cell transplantation, Aplastic anemia, BONE-MARROW-TRANSPLANTATION, DIAGNOSIS
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objective: Although inhibition of the complement system at different steps is a promising therapy modality in patients with paroxysmal nocturnal hemoglobinuria (PNH), allogeneic hematopoietic stem cell transplantation (HCT) is still the only curative therapy, especially for patients with intractable hemolysis or bone marrow failure. The aim of this study is to evaluate the outcomes of allogeneic HCT in PNH patients with aplastic anemia (PNH-AA) or without.