Hematopoietic Stem Cell Transplantation for Patients with Paroxysmal Nocturnal Hemoglobinuria with or without Aplastic Anemia: A Multicenter Turkish Experience

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Yilmaz F., SOYER N., Seval G. C., Bozdag S. C., TOPÇUOĞLU P., ÜNAL A., ...More

TURKISH JOURNAL OF HEMATOLOGY, vol.38, no.3, pp.195-203, 2021 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.4274/tjh.galenos.2021.2021.0105
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.195-203
  • Keywords: Paroxysmal nocturnal hemoglobinuria, Transplantation, Allogeneic stem cell transplantation, Aplastic anemia, BONE-MARROW-TRANSPLANTATION, DIAGNOSIS
  • Hacettepe University Affiliated: Yes

Abstract

Objective: Although inhibition of the complement system at different steps is a promising therapy modality in patients with paroxysmal nocturnal hemoglobinuria (PNH), allogeneic hematopoietic stem cell transplantation (HCT) is still the only curative therapy, especially for patients with intractable hemolysis or bone marrow failure. The aim of this study is to evaluate the outcomes of allogeneic HCT in PNH patients with aplastic anemia (PNH-AA) or without.