Radiation-induced molecular imprinting Of D-glucose onto poly(2-hydroxyethyl methacrylate) matrices using various crosslinking agents


Ates Z., Guven O.

RADIATION PHYSICS AND CHEMISTRY, cilt.79, ss.219-222, 2010 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 79 Konu: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.radphyschem.2009.10.010
  • Dergi Adı: RADIATION PHYSICS AND CHEMISTRY
  • Sayfa Sayıları: ss.219-222

Özet

Radiation-induced molecular imprinting Of D-glucose onto poly(2-hydroxyethyl methacrylate) matrix was achieved to create three-dimensional cavities to recognize and bind D-glucose. The optimization of imprinting capability of matrices was achieved by investigating the effects of various parameters such as the type and amount of crosslinking agent, type of solvent, template to monomer ratio and total absorbed dose. Crosslinking agents with increasing chain lengths and different flexibilities were used in an attempt to elucidate the impact of relevant imprint parameters on the effectiveness of imprinting technique. The absorbed dose varied from I to 15 kGy. Cavity sizes of MIPs were measured by positron annihilation lifetime (PAL) experiments. Control matrices were synthesized with exactly the same composition in the absence of D-glucose. Separation Of D-glucose has been shown to be successfully achieved in HPLC columns filled with MIPs whereas no separation was observed for non-imprint matrices. (C) 2009 Elsevier Ltd. All rights reserved.