Arg753Gln TLR-2 polymorphism in familial Mediterranean fever: Linking the environment to the phenotype in a monogenic inflammatory disease

Ozen S., Berdeli A., Turel B., Kutlay S., Yalcinkaya F., Arici M., ...More

JOURNAL OF RHEUMATOLOGY, vol.33, no.12, pp.2498-2500, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 12
  • Publication Date: 2006
  • Journal Name: JOURNAL OF RHEUMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2498-2500
  • Hacettepe University Affiliated: Yes

Abstract

Objective. Familial Mediterranean fever (FMF) is an autoinflammatory disease common in eastern Mediterranean populations. The most severe complication is the development of secondary amyloidosis. Toll-like receptor (TLR-2) plays a critical role in linking the recognition of microbes to immune activation. We investigated whether the Arg753Gln TLR2 polymorphism affected the development of secondary amyloidosis in patients with FMT.