Arg753Gln TLR-2 polymorphism in familial Mediterranean fever: Linking the environment to the phenotype in a monogenic inflammatory disease
JOURNAL OF RHEUMATOLOGY, cilt.33, sa.12, ss.2498-2500, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 12
- Basım Tarihi: 2006
- Dergi Adı: JOURNAL OF RHEUMATOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.2498-2500
- Hacettepe Üniversitesi Adresli: Evet
Özet
Objective. Familial Mediterranean fever (FMF) is an autoinflammatory disease common in eastern Mediterranean populations. The most severe complication is the development of secondary amyloidosis. Toll-like receptor (TLR-2) plays a critical role in linking the recognition of microbes to immune activation. We investigated whether the Arg753Gln TLR2 polymorphism affected the development of secondary amyloidosis in patients with FMT.