Renal safety and extrahepatic defluorination of sevoflurane in hepatic transplantations

Kanbak, MERAL; KARAGOZ, A.; ERDEM, N.; OC, BAHAR; SARICAOGLU, FATMA; ERTAS, N.; BERKKAN, A.; ABBASOGLU, OSMAN; AYPAR, U.

doi:10.1016/j.transproceed.2007.01.081

Renal safety and extrahepatic defluorination of sevoflurane in hepatic transplantations

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Kanbak M., KARAGOZ A. H., ERDEM N., OC B., SARICAOGLU F., ERTAS N., ...More

TRANSPLANTATION PROCEEDINGS, vol.39, no.5, pp.1544-1548, 2007 (SCI-Expanded)

Publication Type: Article / Article
Volume: 39 Issue: 5
Publication Date: 2007
Doi Number: 10.1016/j.transproceed.2007.01.081
Journal Name: TRANSPLANTATION PROCEEDINGS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1544-1548
Hacettepe University Affiliated: Yes

Abstract

Background. The main metabolic pathway for defluorination of sevoflurane in the liver produces inorganic fluoride (171). The metabolism and effect of sevoflurane on the kidney is not clear during anhepatic phase in liver transplantation. The goal of the present study was to investigate the metabolism and renal effect of sevoflurane by measuring plasma and urine inorganic fluoride, urinary N-acetyl-glucosaminidase (NAG), and plasma creatinine levels in patients undergoing liver transplantations.