T-ALL with monoclonal gammopathy and hairy cell features

Yetgin S. , Olcay L., Yel L., Tuncer M., Tezcan I., Erdemli E., ...Daha Fazla

AMERICAN JOURNAL OF HEMATOLOGY, cilt.65, ss.166-170, 2000 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 65 Konu: 2
  • Basım Tarihi: 2000
  • Sayfa Sayıları: ss.166-170


The presented case is a boy with T-cell acute lymphoblastic leukemia (ALL) with hairy cell (HC) features and monoclonal gammopathy, The disease process had an acute onset and followed a rapid, progressive course. The patient had minimal splenomegaly and bicytopenia, but the bone marrow displayed increased numbers of reticulin fibers. The blasts were positive for tartrate-resistant acid phosphatase (TRAP) and CD11c, Molecular analysis revealed rearrangement of immunoglobulin heavy chain genes and a rearranged T-cell receptor (TcR beta) beta gene. The patient responded to conventional ALL therapy. Acute T-cell ALL with HC features in childhood has not been reported previously, either alone or in association with monoclonal gammopathy, We propose "T-ALL with hairy cell features" to describe this case. (C) 2000 Wiley-Liss, Inc.