An In Vitro Study on the Interactions of Pycnogenol (R) with Cisplatin in Human Cervical Cancer Cells

BECİT M., Aydin S.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.17, no.1, pp.1-6, 2020 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.4274/tjps.galenos.2018.97759
  • Journal Indexes: Emerging Sources Citation Index, Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1-6
  • Keywords: Pycnogenol, cisplatin, cytotoxicity, genotoxicity, human cervix cancer cells, DNA-DAMAGE, ANTICANCER, EXTRACT, GROWTH, BARK


Objectives: In the treatment of cancer, it is intended to increase the anticancer effect and decrease cytotoxicity using various plant-derived phenolic compounds with chemotherapeutic drugs. Pycnogenol (R) (PVC), a phenolic compound, has been the subject of many studies. Since the mechanisms of the interactions of PYC with cisplatin need to be clarified, we aimed to determine the effects of PYC on cisplatin cytotoxicity in human cervix cancer cells (HeLa) and to evaluate the genotoxicity of PYC.