An In Vitro Study on the Interactions of Pycnogenol (R) with Cisplatin in Human Cervical Cancer Cells

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BECİT M., Aydin S.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.17, sa.1, ss.1-6, 2020 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4274/tjps.galenos.2018.97759
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1-6
  • Anahtar Kelimeler: Pycnogenol, cisplatin, cytotoxicity, genotoxicity, human cervix cancer cells, DNA-DAMAGE, ANTICANCER, EXTRACT, GROWTH, BARK
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objectives: In the treatment of cancer, it is intended to increase the anticancer effect and decrease cytotoxicity using various plant-derived phenolic compounds with chemotherapeutic drugs. Pycnogenol (R) (PVC), a phenolic compound, has been the subject of many studies. Since the mechanisms of the interactions of PYC with cisplatin need to be clarified, we aimed to determine the effects of PYC on cisplatin cytotoxicity in human cervix cancer cells (HeLa) and to evaluate the genotoxicity of PYC.