Interferon-alpha and lamivudine combination therapy of children with chronic hepatitis B infection who were interferon-alpha nonresponders


Saltik-Temizel İ. N. , Kocak N., Demir H.

PEDIATRIC INFECTIOUS DISEASE JOURNAL, cilt.23, ss.466-468, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 23 Konu: 5
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1097/01.inf.0000122611.11236.42
  • Dergi Adı: PEDIATRIC INFECTIOUS DISEASE JOURNAL
  • Sayfa Sayıları: ss.466-468

Özet

Greater than one-half of children with chronic hepatitis B infection are nonresponders to interferon-alpha (IFN-alpha). The aim of this study was to investigate the efficacy of lamivudine (LMV) and IFN-alpha combination therapy in these children. Nineteen children were given LMV alone for 3 months; then IFN-alpha was added to LMV for 6 months. Virologic response was achieved in seven (36.8%) patients. LMV and IFN-alpha combination therapy may represent an effective treatment option.