Interferon-alpha and lamivudine combination therapy of children with chronic hepatitis B infection who were interferon-alpha nonresponders

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Atıf İçin Kopyala

Saltik-Temizel İ. N., Kocak N., Demir H.

PEDIATRIC INFECTIOUS DISEASE JOURNAL, cilt.23, sa.5, ss.466-468, 2004 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 23 Sayı: 5
• Basım Tarihi: 2004
• Doi Numarası: 10.1097/01.inf.0000122611.11236.42
• Dergi Adı: PEDIATRIC INFECTIOUS DISEASE JOURNAL
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.466-468
• Hacettepe Üniversitesi Adresli: Evet

Özet

Greater than one-half of children with chronic hepatitis B infection are nonresponders to interferon-alpha (IFN-alpha). The aim of this study was to investigate the efficacy of lamivudine (LMV) and IFN-alpha combination therapy in these children. Nineteen children were given LMV alone for 3 months; then IFN-alpha was added to LMV for 6 months. Virologic response was achieved in seven (36.8%) patients. LMV and IFN-alpha combination therapy may represent an effective treatment option.