Histone deacetylase inhibitory properties of metabolites from leaves of <i>Quercus pontica</i> K. Koch and its metabolites

RENDA G., Sevgi S., Soral M., BORA AKOĞLU G., SARI S., Cetin O., ...More

INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH, 2024 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2024
  • Doi Number: 10.1080/09603123.2024.2399210
  • Journal Name: INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Agricultural & Environmental Science Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, CINAHL, Educational research abstracts (ERA), EMBASE, Environment Index, Food Science & Technology Abstracts, Geobase, MEDLINE, Pollution Abstracts, Veterinary Science Database
  • Hacettepe University Affiliated: Yes

Abstract

The infusions prepared from some Quercus L. species are used in folk medicine for medicinal purposes and consumed as tea. Quercus pontica K. Koch was selected in this study, for which no phytochemical isolation studies have been performed so far. Quercetin 3-O- beta-D-glucopyranoside, kaempferol 3-O-(6""-O-galloyl)-beta-D-glucopyranoside, kaempferol 3-O-beta-D-glucopyranoside, kaempferol 3-O-(6"'-coumaroyl-beta-D-glucopyranoside, phlorizin, rosmarinic acid, and catechin were isolated from the titled plant for the first time. Some polyphenolic compounds have been shown to inhibit histone deacetylase (HDAC) enzymes. However, there is no study on the any activities of Quercus species in the literature. In this study, we demonstrated that the extract has in vitro pan-HDAC inhibition activity. Through a virtual screening study, the compounds were found to inhibit HDAC7 more strongly than the other HDAC isoforms; therefore, the HDAC7 inhibition activities were studied in vitro. Kaempferol 3-O-beta-D-glucopyranoside and kaempferol 3-O-(6'"-coumaroyl-beta-D-glucopyranoside) showed the best anti-HDAC7 activity with 37% and 41% inhibition at 500 mu M.