EFFECT OF LIPOSOMAL ENCAPSULATION OF CHLORAMPHENICOL ON ITS TRANSFER ACROSS THE HUMAN PLACENTA IN A DUAL INVITRO PERFUSION SYSTEM


ONUR M., KIRBY C., ISIMER A., BEKSAC S., BASCI N. E. , PAMIR R., ...More

INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol.88, pp.313-317, 1992 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 88
  • Publication Date: 1992
  • Doi Number: 10.1016/0378-5173(92)90329-z
  • Journal Name: INTERNATIONAL JOURNAL OF PHARMACEUTICS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.313-317

Abstract

This study attempts to demonstrate that drug transfer from the maternal to the fetal side across the placenta can be controlled by means of drug modifications. For this we encapsulated a teratogenic drug, chloramphenicol, in liposomes of dehydrated-rehydrated type and applied these to an in vitro dual perfusion system in which human placenta was perfused under controlled conditions. Results were compared with those obtained in similar perfusions performed with a solution of free chloramphenicol. We observed a statistically significant decrease in the transfer from the maternal to the fetal side when the drug was applied in liposomal form.