Association Between Prol2Ala Polymorphism of Peroxisome ProliferatorActivated Receptor Gamma (PPAR gamma) and Components of Metabolic Syndrome

BÜYÜKTUNCER DEMİREL Z., KÖKSAL G., DAĞDELEN S., Geyik P. O., Isildak M., Erbas T.

TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM, vol.14, no.3, pp.54-59, 2010 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 3
  • Publication Date: 2010
  • Journal Name: TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.54-59
  • Hacettepe University Affiliated: Yes

Abstract

Objective: Metabolic syndrome is a highly prevalent complex disorder characterized by abdominal obesity, insulin resistance, dyslipidemia and hypertension. It occurs as a result of the interaction between genetic susceptibility and environmental factors, in particular, diet. The pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma (PPAR gamma), which generates a genetic diversity has been proposed to act in the pathogenesis of metabolic syndrome. The objectives of this study were to verify whether PPAR gamma Pro12Ala polymorphism modulates the prevalence of the components of metabolic syndrome and whether dietary intake interacts with the polymorphism to modulate the features of syndrome.