New steroidal glycosides from the fruits of Tribulus terrestris

Bedir E., Khan I.

JOURNAL OF NATURAL PRODUCTS, vol.63, no.12, pp.1699-1701, 2000 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 12
  • Publication Date: 2000
  • Doi Number: 10.1021/np000353b
  • Journal Name: JOURNAL OF NATURAL PRODUCTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1699-1701
  • Hacettepe University Affiliated: No

Abstract

Three new steroidal saponins (1-3) were isolated from the fruits of Tribulus terrestris. Their structures were assigned by spectroscopic methods (IR, HRESIMS, 1D- and 2D-NMR) as 26-O-beta -D-glucopyranosyl-(25S)-5 beta -furost-20(22)-en-3 beta ,26-diol-3-O-alpha -L-rhamnopyranosyl-(1->2)-[alpha -L-rhamnopyranosyl-(1->4)]-beta -D-glucopyranoside (1), 26-O-beta -D-glucopyranosyl-(25S)-5 beta -furost-20(22)-en-3 beta ,26-diol-3-O-alpha -L-rhamnopyranosyl-(1->2)- [beta -D-glucopyranosyl-(1->4)]-beta -D-galactopyranoside (2), and 25(S)-5 beta -spirostan-3 beta-alpha -3-O-alpha -L-rhamnopyranosyl-(1->2 -[beta -D-glucopyranosyl-(1->4)]-beta -D-galactopyranoside (3). Compound 3 showed cytotoxicity against a human malignant melanoma cell line (SK-MEL).