New steroidal glycosides from the fruits of Tribulus terrestris


Bedir E., Khan I.

JOURNAL OF NATURAL PRODUCTS, cilt.63, ss.1699-1701, 2000 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 63 Konu: 12
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1021/np000353b
  • Dergi Adı: JOURNAL OF NATURAL PRODUCTS
  • Sayfa Sayıları: ss.1699-1701

Özet

Three new steroidal saponins (1-3) were isolated from the fruits of Tribulus terrestris. Their structures were assigned by spectroscopic methods (IR, HRESIMS, 1D- and 2D-NMR) as 26-O-beta -D-glucopyranosyl-(25S)-5 beta -furost-20(22)-en-3 beta ,26-diol-3-O-alpha -L-rhamnopyranosyl-(1->2)-[alpha -L-rhamnopyranosyl-(1->4)]-beta -D-glucopyranoside (1), 26-O-beta -D-glucopyranosyl-(25S)-5 beta -furost-20(22)-en-3 beta ,26-diol-3-O-alpha -L-rhamnopyranosyl-(1->2)- [beta -D-glucopyranosyl-(1->4)]-beta -D-galactopyranoside (2), and 25(S)-5 beta -spirostan-3 beta-alpha -3-O-alpha -L-rhamnopyranosyl-(1->2 -[beta -D-glucopyranosyl-(1->4)]-beta -D-galactopyranoside (3). Compound 3 showed cytotoxicity against a human malignant melanoma cell line (SK-MEL).