Synthesis and antioxidant properties of some new flavone derivatives on lipid peroxidation in the rat liver

Tuncbilek M., Ayhan-Kilcigil G., Ertan R., Can-Eke B., Iscan M.

PHARMAZIE, vol.55, no.5, pp.359-361, 2000 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 5
  • Publication Date: 2000
  • Journal Name: PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.359-361
  • Hacettepe University Affiliated: No


A series of 2'-, 3'-, 4'- and 6-substituted flavone derivatives was synthesized and their in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels were determined. Retinoic acid, at 10(-4) M concentration, decreased the LP level by about 34%. A significant decrease in male liver microsomal LP level was noted for the compounds 3d, 1a, 3b and 4b at a concentration of 10(-4) M (100%, 95%, 75% and 62%, respectively).