Spinal 5-HT7 Receptors Play an Important Role in the Antinociceptive and Antihyperalgesic Effects of Tramadol and Its Metabolite, O-Desmethyltramadol, via Activation of Descending Serotonergic Pathways

Yanarates, Omer; Dogrul, Ahmet; Yildirim, Vedat; ŞAHİN, ALTAN; Sizlan, Ali; Seyrek, Melik; Akgul, Ozguer; Kozak, Orhan; Kurt, Ercan; Aypar, Ulku

doi:10.1097/aln.0b013e3181cd7920

Spinal 5-HT7 Receptors Play an Important Role in the Antinociceptive and Antihyperalgesic Effects of Tramadol and Its Metabolite, O-Desmethyltramadol, via Activation of Descending Serotonergic Pathways

Yanarates O., Dogrul A., Yildirim V., ŞAHİN A., Sizlan A., Seyrek M., ...Daha Fazla

ANESTHESIOLOGY, cilt.112, sa.3, ss.696-710, 2010 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 112 Sayı: 3
Basım Tarihi: 2010
Doi Numarası: 10.1097/aln.0b013e3181cd7920
Dergi Adı: ANESTHESIOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.696-710
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Tramadol is an analgesic drug, and its mechanism of action is believed to be mediated by the mu-opioid receptor. A further action of tramadol has been identified as blocking the reuptake of serotonin (5-HT). One of the most recently identified subtypes of 5-HT receptor is the 5-HT7 receptor. Thus, the authors aimed to examine the potential role of serotonergic descending bulbospinal pathways and spinal 5-HT7 receptors compared with that of the 5-HT2A and 5-HT3 receptors in the antinociceptive and antihyperalgesic effects of tramadol and its major active metabolite O-desmethyltramadol (M1) on phasic and postoperative pain models.