Spinal 5-HT7 Receptors Play an Important Role in the Antinociceptive and Antihyperalgesic Effects of Tramadol and Its Metabolite, O-Desmethyltramadol, via Activation of Descending Serotonergic Pathways

Yanarates O., Dogrul A., Yildirim V., ŞAHİN A. , Sizlan A., Seyrek M., ...Daha Fazla

ANESTHESIOLOGY, cilt.112, ss.696-710, 2010 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 112 Konu: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1097/aln.0b013e3181cd7920
  • Sayfa Sayıları: ss.696-710


Background: Tramadol is an analgesic drug, and its mechanism of action is believed to be mediated by the mu-opioid receptor. A further action of tramadol has been identified as blocking the reuptake of serotonin (5-HT). One of the most recently identified subtypes of 5-HT receptor is the 5-HT7 receptor. Thus, the authors aimed to examine the potential role of serotonergic descending bulbospinal pathways and spinal 5-HT7 receptors compared with that of the 5-HT2A and 5-HT3 receptors in the antinociceptive and antihyperalgesic effects of tramadol and its major active metabolite O-desmethyltramadol (M1) on phasic and postoperative pain models.