Surface enhanced Raman spectroscopy as a novel tool for rapid quantification of heroin and metabolites in saliva

AKÇAN R., Yildirim M. S., İLHAN H., GÜVEN B., TAMER U., SAĞLAM N.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.50, sa.5, ss.1470-1479, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 5
  • Basım Tarihi: 2020
  • Doi Numarası: 10.3906/sag-1912-196
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1470-1479
  • Anahtar Kelimeler: Heroin and morphine identification, Heroin and morphine quantification, surface-enhanced Raman spectroscopy (SERS), Raman-active surface, gold nanorod arrays, silver nanoparticles, LIQUID-CHROMATOGRAPHY, QUANTITATIVE-ANALYSIS, GOLD NANOPARTICLES, IDENTIFICATION, DRUGS, COCAINE, BLOOD, MORPHINE, ABUSE
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Heroin can be detected and quantified by certain analytical methods, however, forensic professionals and criminal laboratories study for cheaper and faster detection tools. Surface-enhanced Raman spectroscopy (SERS) rises as a possible alternative tool with its widening application spectra. There are few studies regarding Raman and SERS spectra of heroin and its metabolites, which are unfortunately controversial. In this study, we compared five different surfaces in order to find out more efficient Raman-active substrate for opiate detection and rapid quantification of heroin and its metabolites in saliva.