Chronic Hemolysis, Oxidative Stress and Inflammation Contribute to Dysfunctional HDL in Sickle Cell Disease

Yalçinkaya A., Ünal S., Er Öztaş Y.

Blood, vol.130, no.S1, pp.2240-2241, 2017 (Peer-Reviewed Journal)

  • Publication Type: Article / Abstract
  • Volume: 130 Issue: S1
  • Publication Date: 2017
  • Doi Number: 10.1182/blood.v130.suppl_1.2240.2240
  • Journal Name: Blood
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.2240-2241


Hypocholesterolemia was observed in sickle cell disease (SCD) patients according to various reports in the literature. It was previously linked to anemia and inflammation by others and to oxidative stress by our group. In this study we investigated the relationship between cholesterol metabolism, hemolysis, inflammation and oxidative stress in SCD.